Total synthesis of sanguiin H-5.
نویسندگان
چکیده
Using an atropdiastereoselective oxidative biaryl coupling as the key step, the total synthesis of the ellagitannin natural product sanguiin H-5 is reported. Both organomagnesium and organozinc based metalation methodologies were used to efficiently construct the strained medium-ring core of the natural product.
منابع مشابه
Synthesis of Biaryl-Containing Medium-Ring Systems by Organocuprate Oxi- dation: Applications in the Total Synthesis of Ellagitannin Natural Products
SYNTHESIS 2009, No. 22, pp 3880–3896xx.xx.2009 Advanced online publication: 07.10.2009 DOI: 10.1055/s-0029-1218154; Art ID: Z36709SS © Georg Thieme Verlag Stuttgart · New York Abstract: In this feature article we discuss the construction of biaryl-containing medium-sized rings by organocuprate oxidation and the application of this chemistry in the synthesis of members of the ellagitannin family...
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ورودعنوان ژورنال:
- Organic letters
دوره 10 12 شماره
صفحات -
تاریخ انتشار 2008